Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli JM109 cells | Neisseria meningitidis |
Protein Variants | Comment | Organism |
---|---|---|
C185A | active site mutant | Neisseria meningitidis |
C185A | the mutant shows improved binding to plasminogen | Neisseria meningitidis |
K230A | the mutant shows impaired binding to plasminogen | Neisseria meningitidis |
K230A/K244A | the mutant shows impaired binding to plasminogen | Neisseria meningitidis |
K244A | the mutant shows slightly impaired binding to plasminogen | Neisseria meningitidis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
epsilon-aminocapronic acid | - |
Neisseria meningitidis |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Neisseria meningitidis | 5737 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Neisseria meningitidis | Q7DDK4 | - |
- |
Neisseria meningitidis MC58 | Q7DDK4 | - |
- |
Purification (Comment) | Organism |
---|---|
Ni Sepharose column chromatography and Sephadex G-25 gel filtration | Neisseria meningitidis |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Prx5-Grx is a plasminogen-binding protein | Neisseria meningitidis | ? | - |
- |
|
additional information | Prx5-Grx is a plasminogen-binding protein | Neisseria meningitidis MC58 | ? | - |
- |
Synonyms | Comment | Organism |
---|---|---|
peroxiredoxin-glutaredoxin | - |
Neisseria meningitidis |
Prx5-Grx | - |
Neisseria meningitidis |
General Information | Comment | Organism |
---|---|---|
malfunction | the enzyme-deficient mutant has a survival defect in human whole blood compared with the parental or complemented strain | Neisseria meningitidis |
physiological function | the enzyme plays an important role in meningococcal pathogenesis and enhances meningococcal survival under oxidative stress | Neisseria meningitidis |